Optimization of Brush-Like Cationic Copolymers for Nonviral Gene Delivery
نویسندگان
چکیده
منابع مشابه
Toxicogenomics of Nonviral Cationic Gene Delivery Nanosystems
To date, both viral and nonviral vectors have been exploited for delivery of gene-based therapies to target cells/tissues. Despite high efficiency of the viral vectors (e.g., retroviruses and adenoviruses), these vectors appear to be immunogenic and potentially harmful when used in clinical gene therapy protocols (Ferber, 2001b). Besides, the preparation and purification of the viral vectors ap...
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Lipid-mediated delivery of DNA into cells holds great promise both for gene therapy and basic research applications. This paper describes the efficient and facile synthesis and the characterization of a new multivalent cationic lipid with a double-branched headgroup structure for gene delivery applications. The synthetic scheme can be extended to give cationic lipids of different charge, spacer...
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ژورنال
عنوان ژورنال: Biomacromolecules
سال: 2012
ISSN: 1525-7797,1526-4602
DOI: 10.1021/bm301747r